Daily Archives: April 3, 2017

Taconic Biosciences Launches ExpressMODEL™, a New Accelerated Model Generation Service

HUDSON, N.Y., April 03, 2017 (GLOBE NEWSWIRE) — Taconic Biosciences, a global leader in genetically engineered mouse models and associated services, has launched ExpressMODEL™, an innovative and streamlined model generation service that reduces the timeline to first generation and experimental cohort by up to four months.

This novel model generation method significantly reduces the time required to create an experimental rodent cohort, enabling critical drug discovery testing to happen much faster, saving both time and money.

ExpressMODEL™ leverages Taconic’s extensive in vitro fertilization (IVF) expertise, optimizing procedures by using chimaeras to rapidly expand founder mice. This increases the number of mice carrying targeted alleles in the first generation from 3-4 to at least 20-30.  By providing a sizeable colony of first generation heterozygous animals, ExpressMODEL™ allows researchers to skip at least one round of colony expansion, saving 3-4 months on the overall project timeline. Elimination of natural breeding in the germline transmission step results in predictable timelines and better experiment planning.

Unlike other methods employed to reduce timelines, ExpressMODEL™ does not rush critical genome modification procedures. The new Taconic approach preserves the use of stringent controls during the genome modification process, thereby minimizing the risk of generating a mouse model carrying the wrong transgenic allele or additional unwanted mutations.

“In drug discovery it is rare to find an innovation that saves time while increasing quality, as typically one is pursued at the expense of the other.  ExpressMODEL™ represents a tremendous value for our customers because it can save up to four months of time, while creating more predictable timelines and consistent high quality,” shared John Couse, PhD, Portfolio Director for Taconic Scientific Services.

“Our model generation work is not done when we have a founder or breeding pair. With ExpressMODEL™, we provide our clients with research-ready cohorts so they can start their work immediately,” said Couse.

Taconic is a fully-licensed provider of rodent model generation services and has twenty years of model design experience, providing gene inactivation, gene mutation or replacement, transgene expression, RNAi, and gene editing via CRISPR/Cas9 technologies to ensure that the right tools are leveraged for each specific customer project.  Complimenting this expertise is Taconic’s unique capability of providing a seamless transition from model design to breeding and colony management, thus offering customers a complete solution.   These scientific services include acquiring or generating, importing, licensing, breeding, testing, preparing, and distributing genetically engineered models to any location worldwide.

To learn more about Taconic’s custom model generation, please call 1-888-TACONIC (888-822-6642) in the US, or +45 70 23 04 05 in Europe, or email info@taconic.com.

About Taconic Biosciences, Inc.
Taconic Biosciences is a fully-licensed, global leader in genetically engineered rodent models and services. Founded in 1952, Taconic helps biotechnology companies and institutions acquire, custom generate, breed, precondition, test, and distribute valuable research models worldwide.  Specialists in genetically engineered mouse and rat models, precision research mouse models, and integrated model design and breeding services, Taconic operates three service laboratories and six breeding facilities in the U.S. and Europe, maintains distributor relationships in Asia and has global shipping capabilities to provide animal models almost anywhere in the world.

Media Contact:
Kelly Owen Grover
Director of Marketing Communications
(518) 697-3824
kelly.grover@taconic.com

King to preside over the promulgation of the new charter

His Majesty King Maha Vajiralongkorn Bodindradebayavarangkun will preside over a ceremony to proclaim the promulgation of the B.E. 2560 Constitution at the Ananta Samakhom throne hall, Dusit Palace on Thursday at about 3 pm.

His Majesty the King will affix his signature on the Constitution to be presented to Prime Minister Prayut Chan-ocha to be placed on a gold tray. The proceedings will be followed by an announcement of the King's speech, proclaiming the promulgation of the Constitution.

The ceremony will be attended by members of the Royal Family, the privy council, the cabinet, the National Legislative Assembly, the Constitution Drafting Committee, presidents of the Supreme court, presidents of independent organizations and members of the diplomatic corp.

Source: Thai Public Broadcasting Service (Thai PBS)

Army top brass apologizes for conscript’s death

Army Commander-in-Chief General Chalermchai Sitthisart on Monday offered an apology to the society and to the family of a conscript who died while being detained at the prison of an army camp in Surat Thani.

He said that the army was ready to take responsibility for the fatal incident and assured fairness to all parties concerned as investigation into the case was under way.

He noted that the incident took place in the prison which was out of sight of most people and he was awaiting for findings by a probe team.

The mother of the victim, Yutkinan Boonniem, lodged a complaint with the Surat Thani provincial police and the military, suspecting that her son was victim of foul play inside the prison.

Earlier, two army officers attached to the camp in Surat Thani were transferred out of the camp, pending an investigation into the case.

Source: Thai Public Broadcasting Service (Thai PBS)

Police to be asked to look for a tourist who provoked an elephant in Khao Yai

The Khao Yai national park will ask the police to look for a tourist who was seen in a widely-shared video footage in the social media provoking a male elephant.

Mr Kanchit Nopsrisuwan, the park chief, said Monday that the video clip which was taken by the tourist himself would be shown to the police by his officials when the lodge a complaint with the police against the unidentified tourist.

He said that yelling and shouting at the elephant in an apparent attempt to provoke the animal would compromise the safety of the other tourists.

A veterinarian attached to the Department of National Parks, Wildlife and Plants Conservation, Mr Pattharaphol Manee-on, said that the tourist in question might be ignorant or clamorous.

He noted that yelling or shouting could irrigate an elephant, resulting to a sudden change of behavior.

He disclosed that the elephant in question, Yoyo, was easily provoked because of the wounds he sustained from fights with the other elephants. He said an angry elephant could pose a threat to people nearby.

Provoking an elephant and then posting the action in the social media is not something to be proud of,' said Mr Pattharaphol as he pleaded with the tourist to come out to show his responsibility.

Source: Thai Public Broadcasting Service (Thai PBS)