Department of Medical Sciences in collaboration with Japan and the Microbial Genome Research Center Research work in Chiang Rai province decoding the genes of endemic tuberculosis found Lineage 2 strains, which are highly infectious and often drug-resistant. And 20-40 percent of patients found have a history of incarceration, aiming for 2023 to decode 700 tuberculosis genes, hoping to use genetic information to increase control efficiency. and end tuberculosis
Dr. Suphakit Sirilak, Director-General of the Department of Medical Sciences, revealed that the Department of Medical Sciences together with the National Institute of Infectious Diseases of Japan (National Institute of Infectious Diseases, Japan), the University of Tokyo (The University of Tokyo) and the Microbial Genome Research Center. (CENMIG) Faculty of Science Mahidol University Research found Lineage 2 tuberculosis (Beijing strain), which was found in outbreaks in Central and Eastern Asia, Eastern Europe, South Africa and with multiple outbreaks in northern Thailand.
The research team has been collecting genetic data of tuberculosis for a period of 2017-2020 in Chiang Rai province. Genetic material was extracted for strain detection by whole genome sequencing method. A total of 592 samples were used. Four strains of tuberculosis were identified, namely Lineage 1-4. Indian variety) was the most common at 45.8%, followed by Lineage 2 (Beijing) at 39.9%. person Tuberculosis comes from both the Indian Ocean tuberculosis strains. and from species from the East Asian region But when analyzing only the cluster analysis from the genetic data of M. tuberculosis Found in lineage 2 strains up to 46 percent. 2 This strain has a high invasive ability and is often resistant to drugs. In addition, there were also outbreaks that were large clusters. There are 10 or more tuberculosis patients in 4 outbreaks, with 20-40% of the patients having a history of being inmates. There was a statistically significant correlation with the outbreak, about 4 times more than patients without prison history. Some patients developed tuberculosis symptoms after being incarcerated for 10 years.
Director General, Department of Medical Sciences further said Currently, Thailand conducts searches for TB patients and TB contacts. for the diagnosis and treatment of tuberculosis and latent tuberculosis Therefore, networks If assessed, there are patients in this risk group, such as inmates. Tuberculosis screening and latent tuberculosis should be performed. after leaving the prison In order to detect tuberculosis quickly, reduce the chance of death from tuberculosis. Comprehensive tuberculosis control in the event of an epidemic Emphasizing that the best prevention of tuberculosis is to find TB patients quickly and complete treatment to reduce the spread of infection
Department of Medical Sciences Continued work on whole-genome transcription of M. tuberculosis. To support the national strategy to end tuberculosis, by 2023, the goal is to decode 700 tuberculosis genetic codes, with the expectation that it will be able to expand the use of tuberculosis genetic information to identify outbreaks and increase investigation efficiency. And can control the disease in other areas further.
Source: Thai News Agency